Network Rail has said that ongoing work to upgrade the Midland Main Line may cause disruption over the weekend of 13 and 14 April.
To allow the work to take place safely, some lines between Bedford and Kettering will be closed meaning that a reduced train service will be in operation.
Two trains an hour will run between London St Pancras and Bedford and there will be a coach replacement service between Bedford and Corby.
This will connect to an hourly rail service between Corby and Nottingham, and an hourly service between Corby and Sheffield via Kettering and Derby.
Passengers planning to travel during this time are strongly advised to check before they travel via National Rail Enquiries or with their train operator.
The works are part of the construction of an additional line between Bedford and Kettering.
Over this one April weekend, engineers will install equipment near Wellingborough that will allow trains to move from one piece of track to another.
Network Rail say it will allow for six trains to London St Pancras per hour by the end of 2020.
Gavin Crook, Principal Programme Sponsor for Network Rail, said: “We would like to urge passengers planning on travelling on the weekend of 13/14 April to plan ahead as there will be a reduced service in operation, as well as coach replacement services.
“There is never an ideal time to carry out work on the railway.
“We do so at weekends as this is a time when fewer people travel, however we do appreciate that this can still have an impact which is why we are working extremely closely with train operators to keep passengers moving.
“The Midland Main Line Upgrade is the biggest investment into the railway since the Victorian era and we look forward to passengers reaping the benefits once completed.”